Orfitus is a surname. Notable people with the surname include:
Memmius Vitrasius Orfitus (died c. 369), Roman politician Servius Cornelius Scipio Salvidienus Orfitus, multiple people, including: Servius Cornelius Scipio Salvidienus Orfitus (consul 51) (died AD 66), Roman senator Servius Cornelius Scipio Salvidienus Orfitus (executed by Domitian), Roman senator Virius Orfitus, Roman statesman