La Flesche may refer to:
People Francis La Flesche (1857–1932), Native American ethnologist Joseph LaFlesche (c. 1822–1888), head chief of the Omaha tribe Marguerite La Flesche Diddock (1862–1945), Native American known for her work with the Office of Indian Affairs Rosalie La Flesche Farley (1861–1900), Native American known for advocating for autonomy of the Omaha Tribe Susan La Flesche Picotte (1865–1915), Native American medical doctor Susette La Flesche (1854–1903), Native American writer
Other uses Susan La Flesche Picotte House, house in Nebraska