The Senio is a river in Italy. Senio may also refer to:
People Senio Kelemete (born 1990), American football player Senio Toleafoa (born 1993), Australian rugby union player John Senio (born 1982), Samoan rugby union player Kevin Senio (born 1978), New Zealand rugby union player
Other uses Palazzuolo sul Senio, commune in Italy