Seyoum is a name. Notable people with the name include:
Seyoum Mengesha (1887–1960), Ethiopian army commander Seyoum Mesfin (1949–2021), Ethiopian politician Seyoum Tesfaye, Ethiopian footballer Seyoum Tsehaye (born 1952), Eritrean journalist Bewketu Seyoum, Ethiopian writer Billene Seyoum (born 1982), Ethiopian politician Estifanos Seyoum (born 1947), Eritrean politician Fentahun Seyoum (born 1971), Israeli politician Mengesha Seyoum (born 1927), Ethiopian prince Stefanos Mengesha Seyoum (born 1952), Ethiopian prince Wolete Israel Seyoum (1907–1989), Ethiopian princess Yanet Seyoum (born 1994), Ethiopian swimmer