Purushothaman is a surname. Notable people with the surname include:
Arun Prabu Purushothaman, Indian film director D. Purushothaman, Indian politician E. Purushothaman, Indian civil servant Kamukara Purushothaman (1930 1995), Indian singer K. M. Purushothaman, Indian civil servant M. K. Purushothaman (died 2013), Indian politician Murali Purushothaman, Indian judge P. Purushothaman (c. 1948–2019), Indian politician Shoba Purushothaman, Malaysian entrepreneur Suguna Purushothaman (1941–2015), Indian vocalist T. G. Purushothaman (born 1979), Indian footballer Vakkom Purushothaman (1928–2023), Indian politician V. N. Purushothaman (1909–1990), Indian politician