The following list shows the NFL players who have thrown the most career interceptions: Brett Favre holds the record for career interceptions thrown in the regular season with 336, while Tom Brady holds the record for career interceptions thrown in the playoffs with 40. Current stats are updated from Pro Football Reference (PFR) all-time interceptions thrown leaders.

Regular season career interceptions thrown leaders

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Based on 200 Career Interceptions No. Name Total Int% 1 Brett Favre ^ 336 3.3% 2 George Blanda ^ 277 6.9% 3 John Hadl 268 5.7% 4 Vinny Testaverde 267 4.0% 5 Fran Tarkenton ^ 266 4.1% 6 Norm Snead 257 5.9% 7 Johnny Unitas ^ 253 4.9% 8 Dan Marino ^ 252 3.0% 9 Peyton Manning ^ 251 2.7% 10 Y. A. Tittle ^ 248 5.8% 11 Jim Hart 247 4.9% 12 Eli Manning 244 4.5% 13 Drew Brees ^ 243 2.3% Bobby Layne ^ 6.6% 15 Dan Fouts ^ 242 4.3%16 Warren Moon ^ 233 3.4%17 John Elway ^ 226 3.1% 18 John Brodie 224 5.0%19 Ken Stabler ^ 222 5.9% 20 Joe Namath ^ 220 5.8% Babe Parilli 6.6% 22 Tom Brady 212 1.8% Philip Rivers 2.6%23 Ben Roethlisberger 211 2.5%25 Terry Bradshaw ^ 210 5.4%26 Joe Ferguson 209 4.6% 27 Steve Grogan 208 5.8% 28 Drew Bledsoe 206 3.1% 29 Steve Deberg 204 4.1%30 Sammy Baugh ^ 203 6.8%31 Matthew Stafford * 202 2.3% Note Y. A. Tittle also threw 27 interceptions while playing for the defunct Baltimore Colts Franchise of the All-America Football Conference in 1948 & 1949, but those stats were not included until 2025.

Playoff leaders

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Statistics accurate as of the end of 2025–26 NFL playoffs

Based on 15 Career Interceptions No. Name Total Int% 1 Tom Brady 40 2.1% 2 Brett Favre ^ 30 3.8% 3 Jim Kelly ^ 28 5.1% Ben Roethlisberger 3.6% 5 Terry Bradshaw ^ 26 6.6% 6 Peyton Manning ^ 25 2.4% 7 Dan Marino ^ 24 3.5% 8 John Elway ^ 21 3.2% Joe Montana 2.9% 10 Roger Staubach ^ 19 4.6% 11 Otto Graham ^ 17 5.7% Fran Tarkenton ^ 5.8% Donovan McNabb 2.9% George Blanda ^ 9.0% Troy Aikman ^ 3.4% 16 Dan Fouts ^ 16 5.6% Craig Morton 7.0% Danny White 4.4% 19 Drew Brees ^ 15 2.1%

References