Zampini is an Italian surname. Notable people with the surname include:
Augusto Zampini (born 1969), Argentine priest Barbara Zampini (born 1978), Argentine musician Carina Zampini (born 1975), Argentine actress Cassandra Zampini (born 1983), American visual artist Donato Zampini (1926–2007), Italian racing cyclist Fanny Zampini Salazar (1853–1931), Italian writer, editor, and lecturer