Tyron Mandrusiak is an Australian former professional rugby union player.

A St Laurence's College product, Mandrusiak was a goal-kicking fly-half and fullback. He played his rugby for Brisbane club Souths and featured for the Queensland Reds in the first two Super 12 seasons. A rugby sevens international, Mandrusiak represented Australia at the 1998 Commonwealth Games.

Mandrusiak is director of sport at St Joseph's College, Gregory Terrace.

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