Di Franco (also spelled DiFranco) or DeFranco is a surname. Notable people with the surname include:
Di Franco Ani DiFranco (born 1970), American-Canadian singer-songwriter Debbie DiFranco, American politician Doug DiFranco, American hip hop producer from the duo Double Dee and Steinski Francisco Di Franco (born 1995), Argentine professional footballer Gianluigi Di Franco (1953–2005), Italian singer Giovanni Cola di Franco (fl. early 1600), Italian Mannerist architect Loretta Di Franco (1942–2024), American operatic soprano Luigi Di Franco (1918–?), Italian footballer
DeFranco Buddy DeFranco (1923–2014), American jazz clarinetist Philip DeFranco (born 1985), American YouTube personality The DeFranco Family, Canadian 1970s pop music group
See also Loreto de Franchis (1578–1638), Italian Catholic prelate Franco (disambiguation)