100 Bullets is a fictional crime drama published by Vertigo, an imprint of DC Comics. As with other noir and pulp characters, both protagonists and antagonists of 100 Bullets are deeply flawed.

The Trust Notable members Augustus Medici First appearing in issue #5, he is Trust's most powerful member. Augustus is the de facto leader of the thirteen families and has plans to bring peace to the rivalries that plague the Trust. Since the death of Daniel Peres, Augustus became even more powerful and has consolidated his position by removing the Peres family from power. Other family heads are now plotting against him. Through Shepherd, Augustus monitored Graves and his schemes, as well as his son. Later events have forced him to deal directly with Graves and accede to Lono's suggestion to pardon Kotias and Vasco for their participation in a failed scheme to assassinate him. It seems that his power is ever increasing, with all the remaining houses dominated by his position. It also seems that he had an agreement with Graves and Vasco about protecting Rothstein. It is eventually revealed that Augustus, Graves and Vasco were the masterminds behind a decades-long plan to assume control of the Trust, a plot which drove most of the series' events and many characters' motives. With the death of Vasco, both Augustus and Graves agreed to a sit down with the remaining houses, with Augustus prepared to discuss the terms of what he termed his "surrender" to the newly aligned Trust power of Megan Dietrich, Tibo Vermeer, and Joan D'Arcy. Augustus then negotiated the appointment of the House of Vasco to Agent Graves, before stepping down to hand the House of Medici to his son, Benito. In issue #100, Benito is killed by the remaining houses, minus Graves. Graves confronts Augustus, stating that he knew his actions would lead to his son's death, but before this can be confirmed, it is revealed that Lono is in Augustus' chair. After Dizzy shoots Lono, Graves executes the unarmed Augustus.

Benito Medici First appearing in issue #20, Augustus' son and heir apparent, mentored by Mr. Shepherd, Benito is a spoiled and reckless young man with a seeming excess of luck who is more interested in gambling than in his responsibilities towards life or the future of the Trust. A botched attempt made on his life on the orders of Fulvio Carlito, as well as Mr. Shepherd's death later on, led him to reassess his priorities. He was pursued by Megan Dietrich but appeared enamored of Dizzy Cordova, whom he tracked down to Mexico. There, he spent time living with Dizzy, Wylie Times and Mr. Branch. After his incapacitation at the hands of Victor Ray and an interrogation by Lono, Benito was reminded of his importance within the Medici Family, and to the Trust at large. Returning to the Medici estate in Florida, Benito seemed to have given his future inheritance more thought. He ordered Lono to capture a Minuteman as a gift for his father, but when Lono returned with a beaten and bound Dizzy Cordova, Benito shot Lono in the face, as an attempt to kill his own family's warlord. Benito then tended to Dizzy's injuries. After Javier Vasco's assassination, Augustus returned home to meet with the remaining leaders of the Trust, from the houses of Dietrich, Vermeer and D'Arcy. The meeting resulted in Augustus' removal of himself from power, and the elevation of Benito to head of the House of Medici. Benito was then immediately found strangled and drowned to death in issue #100. Graves claims Benito's death was engineered intentionally by his father and the younger Trust did it, but it is also hinted that Lono killed him in revenge for Benito's shooting his face.

Megan Dietrich First appearing in issue #4, she is series' femme fatale; a charming, confident yet deadly member of the Trust. Megan had risen to become the head of the Los Angeles-based Dietrich family, also running the family securities firm following the death of her father. A seemingly staunch supporter of the House of Medici and a close friend of Augustus, Megan had a hidden agenda and was not above murder to protect her own interests, also displaying more than a passing interest in Benito Medici. Megan was shot in an intentionally unsuccessful assassination attempt by Victor in San Diego (in issue #66). Soon after, she consummated a deeper partnership with Augustus Medici, who was able to convince Megan to not seek retribution for the attempt on her life. Megan's relationship with Augustus appeared to be headed towards a possible marriage, but the relationship was terminated by Augustus. Megan then teamed up with Vermeer and D'Arcy as they plotted against Medici and Graves to realign the Trust under her leadership. In issue #99, she was seen seducing Benito (the brand new head of the house of Medici) in the pool where he would be found dead in the next issue. She was shown to be possibly both racist and sexist in issue #100, when she reacted to Graves' naming of Dizzy Cordova as the new Agent of the Minutemen. Megan was killed in an explosion engineered by Cole Burns (which also ultimately claimed his life as well) in issue #100.

Roland Dietrich First appearing in issue #69 (in a flashback), Roland was Megan's father and the Head of the House of Dietrich around the time of the Atlantic City incident. He was present in the 1962 meeting at which he and Axel Nagel approved Graves's ascension to the role of Agent and leader of the Minutemen. He voted in favor of the Trust's dissolution of the Minutemen, on the advice of Graves and despite his reservations. Ultimately, this led to his capture and brutal execution at the hands of the Minutemen in Atlantic City.

Javier Vasco First appearing in issue #25, Javier Vasco's Seattle-based family has historically been viewed as aggressors within the Trust. They have had problems with the Nagel family which were dealt with by the Minutemen, but a rivalry was still evident. Javier was seemingly quite suspicious of the intentions of the House of Medici in restructuring the Trust and eliminating the Minutemen. He had formed a trio of dissent along with Helena Kotias and Fulvio Carlito, planning to eliminate Augustus Medici with the apparent agreement of Graves, in return for his reinstitution. Javier persuaded Axel Nagel to commit suicide, apparently as a consequence of some obligation. It was recently revealed that Augustus, Graves and Vasco were the masterminds behind a decades-long grand plan that is only now becoming clear, which included Vasco feinting the opposition role. He was eliminated by Will Slaughter in issue #98, who was contracted for the hit by Joan D'Arcy. His House is eventually handed over to Graves in the Trust's realignment.

Helena Kotias First appearing in issue #25, based in Aspen, Colorado, Helena was unhappy with the leadership of the Trust. She was part of the alliance between the Kotias, Carlito and Vasco families determined to remove Augustus Medici from power. The trio met with Agent Graves, offering him to reinstitute the Minutemen in exchange for his help. It appeared that Helena was a very close ally of Javier Vasco and Lono even referred to her House as a wing of the House of Vasco. She is killed by Victor in issue #86 along with another Trust head, Constance Von Hagen.

Mia Simone First appearing in issue #24, based in Dallas, she was another ally of Medici. Graves considered the Simones to be the weakest of the families of the Trust. Mia was close to both Megan Dietrich and the late Daniel Peres, and seemed dismissive of the aggressive influence of the Vasco family within their organisation. She was killed in issue #76 in a fatal fall mysteriously arranged by Remi Rome.

Tibo Vermeer First appearing in issue #25, based in Omaha, Nebraska, it was first speculated that the House of Vermeer was in alliance with the House of Vasco after Vermeer and Javier Vasco approached Lars Nagel in issue #72. Vermeer's true allegiances and motivations are unclear, but seem to be largely based in self-preservation. He was last seen with Megan and D'Arcy, preparing to sit down with Graves and Augustus. He is killed by Cole Burns in issue #100.

Daniel Peres First appearing in issue #23, Daniel Peres was a head of the Peres family and powerful within the Trust. During a summit meeting, Peres delivered a message to Augustus Medici from Graves. Peres tried hard to prevent a war between the former close friends, but was killed by Cole Burns in issue #25. The House of Peres was then absorbed by the other then-12 families.

Peres was killed on the same bench in Atlantic City as Mr. Branch would later be.

Anwar Madrid First appearing in issue #25, based in New Orleans, Anwar Madrid is the father of Rose Madrid and a supporter of Augustus Medici in the elimination of the Minutemen. Anwar also had a personal ax to grind against the Trust's former soldiers because of Wylie's doomed relationship with Rose and her subsequent death. Wylie Times killed Anwar Madrid (in issue #56) shortly after being reactivated as a Minuteman.

Rose Madrid First appearing in issue #52 (in a flashback), daughter of Anwar Madrid and heiress to the House of Madrid, Rose was also secretly romantically involved with Minuteman Wylie Times. This relationship, which broke the rules of both the Trust and the Minutemen, was doomed due to Rose's involvement with a conspiracy against the House of Medici. Rose was executed by Wylie upon Shepherd's orders, causing a rift between the two men. Rose's relationship with Wylie and her death was one of several reasons why the Trust voted in favor of eliminating the Minutemen. It was revealed in a flashback that Rose's plot against Medici was being manipulated by someone within the Trust, which prompted Wylie to agree to Graves' plan to fake the deaths of the Minutemen.

Fulvio Carlito First appearing in issue #25, Fulvio Carlito had been openly critical of the direction in which the Trust was heading. He had formed an alliance with the Kotias and Vasco families to terminate Augustus Medici. The trio induced Agent Graves to not interfere with the achievement of their goals. It was revealed that Carlito was behind a failed assassination attempt of both Augustus and Benito in Miami. Lono's first overt action as the Trust's new Warlord was to capture and torture Fulvio for information concerning the alliance (in issue #65), and to subsequently eliminate the House of Carlito upon his death.

Axel Nagel First appearing in issue #25, an elder member of the Trust, he seemed as skeptical as Vasco about the abandonment of the Minutemen. His family apparently had disagreements with the Vascos which had to be adjudicated by the Minutemen (presumably in a brutal fashion). He was considered an ally of the House of Medici and his family was based in New York City. Axel was instrumental in approving Graves' elevation as the head of the Minutemen in 1962. This was against the wishes of the Trust's then liaison, Mr. Shore, who distrusted Graves' closeness to the Houses of Medici and Vasco. Axel Nagel died in issue #69 after willingly taking poison given by Vasco, who promised Axel to pass the House of Nagel onto his children rather than fold.

Lars and Anna Nagel First appearing in issue #70, they were the twin heirs to the House of Nagel. Before they could decide who will lead the House of Nagel, Anna was deceived by Lono. After Lars finished an unexpected business dinner with Vasco and Vermeer, Lono told Anna that Lars was there trying to ally himself with the men who killed their father. Back at their hotel room, Lars unknowingly drank champagne that Anna spiked with lethal pills. When Lars tells his sister that he had decided that she should assume control over the House of Nagel, Anna tried to stop him from drinking his champagne. Already too late, she swallowed the rest of the pills after her brother's death, an act of suicide. The House of Nagel was absorbed by the other Houses soon after.

Sigmar Rhone