Mary Anna may refer to:
Mary Anna Custis Lee (1807–1873), American wife of Robert E. Lee, slave owner, and socialite Mary Anna Day (1852–1924), American botanist and librarian Mary Anna Draper (1839–1914), American astronomical photographer and researcher Mary Anna Henry (1834–1903), American diarist Mary Anna Jackson (1831–1915), American second wife, and subsequently widow, of Stonewall Jackson Mary Anna Marten (1929–2010), English aristocrat and landowner Mary Anna Needell (1830–1922), English novelist Mary Anna Wyall (1922–2017), American aviator