Mühlstein or Muhlstein is a surname of German origin, either a nickname for a heavy person or a toponymic surname from the historic village of Mühlstein in Baden-Württemberg, Germany, derived from the Middle High German word for millstone. Notable people with the surname include:
Anatol Mühlstein (1889–1957), Polish diplomat and writer Anka Muhlstein (born 1935), French historian and biographer Florian Mühlstein (born 1990), Austrian ice hockey player Jan Mühlstein (born 1949), German Jewish activist and journalist
See also Millstein, an Americanized spelling
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