Millstein is a surname that may either be a variant of Milstein, an occupational Ashkenazi surname for a miller, or an Americanized spelling of German Mühlstein, which may either be a nickname for a heavy person or a toponymic surname from the historic village of Mühlstein in Baden-Württemberg, derived from the Middle High German word for millstone. Notable people with the surname include:
Ira Millstein (1926–2024), American antitrust lawyer, author, and professor Roberta Millstein ( 1988–present), American philosopher and professor Todd Millstein ( 1996–present), American computer scientist and professor
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