USS Seneca has been the name of more than one United States Navy ship, and may refer to:
, a gunboat in commission from 1861 to 1865 , a minesweeper and patrol vessel in commission from 1917 to 1919 , a barge in commission from 1917 to 1919 USS Seneca (SP-1824), the originally planned name and designation of a cargo ship commissioned as and in commission from 1918 to 1919 , a tug in commission from 1943 to 1971