The 1980 South Carolina State Bulldogs football team represented South Carolina State College (now known as South Carolina State University) as a member of the Mid-Eastern Athletic Conference (MEAC) during the 1980 NCAA Division I-AA football season. Led by second-year head coach Bill Davis, the Bulldogs compiled an overall record of 10–1, with a mark of 5–0 in conference play, and finished as MEAC champion.
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