Giandomenico is a given name. Notable people with the given name include:
Giandomenico Boncompagni, a.k.a. Gianni Boncompagni, (1932–2017), Italian television, radio presenter, director, writer, and lyricist Giandomenico Costi (born 1969), Italian footballer Giandomenico De Marchis (1893–1967), Italian sculptor Giandomenico Facchina (1826–1903), Italian mosaic artist Giandomenico Majone (born 1932), Italian scholar of political science Giandomenico Martoretta (1515–1560s?), Italian Renaissance composer Giandomenico Mesto (born 1982), Italian footballer Giandomenico Picco (1948–2024), a.k.a. Gianni Picco, Italian diplomat Giandomenico Ravera, a.k.a. Gianni Ravera, (1920-1986), Italian singer, impresario, and record producer Giandomenico Salvadori (born 1992), Italian cross-country skier Giandomenico Spinola (1580–1646), Italian cardinal
See also Gianni