Famiglietti is an occupational surname of Italian origin, referring to a domestic servant, derived from the old Italian word famiglio. Notable people with the surname include:
Ángel Famiglietti (1927–2001), Panamanian weightlifter Anthony Famiglietti (born 1978), American track and field athlete Gary Famiglietti (1913–1986), American football player James S. Famiglietti, Canadian professor and hydrologist Mark Famiglietti (born 1979/80), American actor, screenwriter, film producer and author Tekla Famiglietti (1936–2020), Italian abbess