The 1980–81 Holy Cross Crusaders men's basketball team represented the College of the Holy Cross during the 1980–81 NCAA Division I men's basketball season. The Crusaders, led by head coach George Blaney, played their home games at the Hart Center and were members of the East Coast Athletic Conference North. They finished the season 20–10, 18–8 in ECAC-South play to finish in second place.
Roster
Schedule
!colspan=9 style=|Regular season
!colspan=9 style=| ECAC North tournament
!colspan=9 style=|NIT tournament
References