RS134-49 is a tetrahydropyridinylindole (THPI) derivative related to psychedelic tryptamines which acts as a 5-HT2A receptor agonist, with a 5-HT2A Ki of 11.5nM and an EC50 of 22nM. It is a biased agonist selective for activation of the Gq coupled signalling pathway with weaker activation of the β-arrestin 2 coupled pathway, but shows a more balanced profile than related compounds such as (R)-69.
See also Cyclized tryptamine Tetrahydropyridinylindole RU-28253 4-Methyl-AMT 4-Methyl-AET 4-Methyl-DMT CP-94253 RU-24969 SN-22 VU6067416
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