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U-93631

U-93631 is a GABAA receptor antagonist. Mechanism of action The mechanism of action of this compound is not entirely clear, but research shows that it binds to the…

U-93631 is a GABAA receptor antagonist.

Mechanism of action The mechanism of action of this compound is not entirely clear, but research shows that it binds to the GABAA receptor. Its binding site seems to be similar to the one of picrotoxin, a potent neurotoxin and convulsant.

The binding of U-93631 decreases the probability of the chloride channel opening and stabilizes the receptor in an inactivated state.

References

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