S80 or S-80 may refer to:
Automobiles Daihatsu Hijet (S80), a kei truck and microvan FAW Senya S80, a crossover Toyota Crown (S80), a sedan Volvo S80, an executive car
Aviation Idaho County Airport, in Grangeville, Idaho, United States Short S.80, a British floatplane Sikorsky S-80, an American helicopter
Consumer electronics Canon PowerShot S80, a digital camera Series 80 (software platform), for mobile phones Yamaha S80, an electric piano
Roads County Route S80 (California), United States County Route S80 (Bergen County, New Jersey), United States S80 Port of Taicang North Port Expressway, China
Submarines
S-80 Plus-class submarine, of the Spanish Navy
Other uses S80, a line of the Vienna S-Bahn in Austria S80, a postcode district for Worksop, England
See also Super 80, aircraft of the McDonnell Douglas MD-80 series