Afzal Hossain (born 1954) is a Bangladeshi actor, director, writer and painter.
Afzal Hossain also may refer to:
Afzal Hossain (Patuakhali politician), incumbent Jatiya Sangsad member from Patuakhali-1 constituency Afzal Hossain (Narayanganj politician), former Jatiya Sangsad member from Dhaka-29 constituency Md. Afzal Hossain, incumbent Jatiya Sangsad member from Kishoreganj-5 constituency Master Afzal Hussain, Indian tailor