The Samuel Butts House (also known as the Samuel Butts House and Store; formerly known as the Mariner's House) is a historic colonial-style building in Portland, Maine, United States. Located in Boothby Square, on Fore Street, the building was completed in 1792,Portland: Historic Resources Inventory – Maine Historic Preservation Committee (1976) when Fore Street was at the shoreline of the Fore River estuary. It is the second-oldest extant building on the Portland peninsula, after the Wadsworth-Longfellow House, which pre-dates it by around six years. It is believed its third storey was added well after the building was completed.

Samuel Butts (1760–1838) was a tailor who moved to Portland from Boston in 1784.

History The building survived the Portland fire of 1866.

A 22-room hotel occupied the building in the first half of the 20th century.

From 1974 to 1981, The Hollow Reed restaurant occupied the storefront.

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