Safrastyan () (alternatively Safrastian () in Classical Armenian orthography) is an Armenian patronymic surname from the given name Safraz (), which is ultimately derived from Persian Sarafrāz (; meaning "head held high", "proud").

Notable people with the surname include:

Aram Safrastyan (1888–1966), Soviet Armenian historian and Turkologist. Arshak Safrastian (1885–1958), British-Armenian diplomat and historian. Ruben Safrastyan (1955—), Armenian historian and Turkologist.

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