Swayne is a surname. It may also refer to:
Schools in the United States Swayne College, Montgomery, Alabama, United States, a school for African Americans from 1868 to 1937 The Swayne School, predecessor of Talladega College, a private, historically black college in Talladega, Alabama Swayne School, that served students from Owyhee, Nevada
Other uses Swayne Latham (1898–1988), American college football quarterback Swayne Hall, Talladega College, a National Historic Landmark Swayne Field, a minor league baseball park in Toledo, Ohio SS Noah H. Swayne, original name of , a World War II cargo ship
See also Sweyn, a Scandinavian given name