Druzhinin is a surname of Russian origin. Notable people with this surname include:
Alexander Druzhinin (1824–1864), Russian writer, translator, and magazine editor Egor Druzhinin (born 1972), Russian actor, director, and choreographer Evgeny Druzhinin (born 1968), Russian entrepreneur and public figure Fyodor Druzhinin (1932–2007), Russian composer Ilya Druzhinin (born 1998), Russian swimmer Petr Druzhinin (born 1974), Russian-Israeli historian and author