Ndwandwe or Ndwandwa is a surname of Ndwandwe Bantu descent. Notable people with the surname include:
LaYaka Ndwandwe, Queen of Swaziland (1780) Tsandzile Ndwandwel, Queen of Swaziland (1868–1875) Nukwase Ndwandwe (–1957), Queen of Swaziland (1938–1957) Lomawa Ndwandwe (died 1938), Queen of Swaziland (1925–1938) Nkosinathi Ndwandwe (born 1959), South African Anglican bishop Zihlathi Ndwandwe (died 1975), Queen of Swaziland (1957–1975) Phila Portia Ndwandwe (1965–1988), uMkhonto we Sizwe guerrilla fighter Sithembiso Ndwandwa (born 1989), South African cricketer Tsepo Ndwandwa (born 1995), South African cricketer Tshepiso Ndwandwa (born 1996), South African cricketer