25N-N1-Nap is a phenethylamine derivative from the 25-NB class, which acts as a potent agonist at the 5-HT2A receptor with weaker activity at 5-HT2B and 5-HT2C. 25N-N1-Nap is a biased agonist, producing robust activation of 5-HT2A coupled signaling pathways mediated by beta arrestin 2, but with little or no activation of pathways mediated via Gq. In animal studies it produces antipsychotic-like effects but without producing the head-twitch response associated with psychedelic activity.
See also 25-NB Non-hallucinogenic 5-HT2A receptor agonist 25N-NBOMe (NBOMe-2C-N) 25N-NBPh RS130-180
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