Manno is a surname. Notable people with the surname include:
Antonio Manno (1739–1810), Italian painter Bob Manno (born 1956), Canadian former ice hockey player Don Manno (1915–1995), American Major League Baseball player Francesco Manno (1754–1831), Italian painter and architect Gaetano Manno (born 1982), German former footballer Giuseppe Manno (1786–1868), Italian magistrate, politician and historian Roger Manno (born 1966), American politician Vincenzo Manno (1949–2018), American operatic tenor and voice teacher