Francesco Santamaria-Nicolini (Naples, 1 July 1830 – Naples, 22 August 1918) was an Italian politician and senator of the Kingdom of Italy.

He was appointed as a senator on 21 November 1892 and was briefly Minister of Justice in the first Giolitti government (8 July - 27 September 1893).

Honours Grand Cordon of the Order of Saints Maurice and Lazarus Grand Cordon of the Order of the Crown of Italy

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