R22 may refer to:
Roads R22 road (Belgium) R-22 regional road (Montenegro) R22 highway (Russia) R22 (South Africa)
Vessels , a destroyer of the Royal Navy , an aircraft carrier of the Indian Navy , a submarine of the United States Navy
Other uses R22 (New York City Subway car) Chlorodifluoromethane, a refrigerant Fiat R.22, an Italian reconnaissance aircraft Ndonga dialect R22: Harmful if swallowed, a risk phrase R-22 Spearhead, a fictional starfighter in the Star Wars universe Robinson R22, an American helicopter R22 refrigerant