Khalife (sometimes spelled Khalifé) is a surname of Middle Eastern origin, and may refer to one of the following people:

Daniel Khalife (born 2001), former British soldier and escaped prisoner Hilda Khalife (born 1973), Arabic TV presenter Ignace Abdo Khalifé, (1914–1998), Lebanese cleric, and the first Eparch of the Maronite Catholic Eparchy of Saint Maron of Sydney in Australia Marcel Khalife (born 1950), Lebanese musical composer, singer, and oud player Peter Khalife (born 1990), Lebanese-Cypriot football agent, manager, and former player Rami Khalifé (born 1981), French-Lebanese composer and pianist Fady Khalife (born 1976), Registered Training Organisation Manager, Melbourne, Australia.

See also Khalifa (disambiguation)