MXB or mxb can refer to:
Message Exchange Bus (MXB), an Iranian cross-platform instant messaging (IM) technology
Andi Jemma Airport, an airport near Masamba, South Sulawesi province, Indonesia, by ICAO code Silacayoapan Mixtec, a language native to central Mexico, by ISO 639 code Malir railway station, a train station in Karachi, Pakistan, by train station code Mex Blue, an airline from Mexico; see List of airline codes