Peluffo is a surname. Notable people with the surname include:
Ana Luisa Peluffo (1929–2026), Mexican actress Luisa Peluffo (born 1941), Argentine writer and journalist Mariano Peluffo (born 1971), Argentine TV host and producer Norberto Peluffo (born 1958), Colombian footballer Vinicio Peluffo (born 1971), Italian politician Daniel Peluffo-Wiese (born 2003), American-born Uruguayan professional footballer