CXE can refer to:
Caicos Express Airways, an airline based in the Turks and Caicos Islands, by ICAO code Chase City Municipal Airport, an airport in Chase City, Virginia, US, by FAA code; see List of airports in Virginia MFS High Income Municipal Trust, an American company listed on the New York Stock Exchange; see Companies listed on the New York Stock Exchange (M) Cosmic X-ray Experiment, an experiment performed by the High Energy Astronomy Observatory 1 telescope