The 2007 Texas Southern Tigers football team represented Texas Southern University as a member of the Southwestern Athletic Conference (SWAC) during the 2007 NCAA Division I FCS football season. Led by fourth-year head coach Steve Wilson, the Tigers compiled an overall record of 0–11, with a mark of 0–9 in conference play, and finished fifth in the West Division of the SWAC.
Head coach Steve Wilson was fired after nine games and was replaced by defensive coordinator DeChon Burns for the team's last two games. Wilson's replacement, Johnnie Cole, was announced on November 30.
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