Kusche is a German surname. Notable people with the surname include:
August Kusche (1869 – 1934), German botanist and entomologist Benno Kusche (1916–2010), German operatic baritone Emily Kusche (born 2002), German actress Larry Kusche (1940–2024), American author, research librarian and pilot Maria Kusche (1928–2012), Spanish art historian of German descent