RSSB may refer to:
Rail Safety and Standards Board, a British non-for-profit independent company Rajasthan Staff Selection Board, selects people for the civil service in Rajasthan, India Radha Soami Satsang Beas, a spiritual organization based in Punjab, India Royal Statistical Society of Belgium RssB, a specialized anti-sigma factor in gene expression RSSB Tigers, a Rwandan professional basketball team