Quaife is a surname. Notable people with the surname include:
Adrian Quaife-Hobbs (born 1991), British racing driver Alan Quaife (1945–2019), Australian rules footballer Barzillai Quaife (1798–1873), British-born editor Bernard Quaife (1899–1984), English cricketer Darlene Quaife (born 1948), Canadian novelist Frank Quaife (1905–1968), English cricketer Geoffrey Robert Quaife, Australian social historian John Quaife (born 1955), retired senior officer of the Royal Australian Air Force Milo Quaife (1880–1959), American historian Phil Quaife (born 1986), British racing driver Pete Quaife (1943–2010), English musician, artist and author Walter Quaife (1864–1943), English cricketer Willie Quaife (1872–1951), English cricketer