Hoyem (and its variant Høyem) is a surname. Notable people with the surname include:
Andrew Hoyem (born 1935), American publisher Lynn Hoyem (1939–1973), American football player Martin Høyem (born 1982), Norwegian football player Olav Jakobsen Høyem (1830–1899), Norwegian teacher Sivert Høyem (born 1976), Norwegian musician Tom Høyem (born 1941), Danish German educator and politician