The Caradine Building is a historic commercial building at 1007 16th Avenue in Monroe, Wisconsin. Elisha Mosher, a merchant and local politician, had the building constructed in 1869. Architect G. F. Schultze of Janesville designed the Victorian building, which was a smaller-scale version of his Baker-Fredendall Building in Janesville. The two-story building's design includes a first-floor storefront with plate glass windows, a brick cornice above the first floor, arched second-story windows with dark brick trim, and a dentillated and corbelled cornice. Dentist W. H. Caradine opened an office on the second floor in 1907, and he purchased the building in 1915; his son and grandson also operated dental practices in the building.

The building was added to the National Register of Historic Places on May 8, 1979.

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