4-Fluoroaniline is an organofluorine compound with the formula . A colorless liquid, it is one of three isomers of fluoroaniline. 4-Fluoroaniline can be prepared by the hydrogenation of 4-nitrofluorobenzene. Applications It is a common building block in medicinal chemistry and related fields. For example, it is a precursor to the fungicide or the fentanyl analogue parafluorofentanyl. It has also been evaluated for the production of ligands for homogeneous catalysis.
Other common uses include in the synthesis of SCH-57871 (the precursor to ezetimibe), difloxacin, basimglurant, revaprazan & in one of the many fluoresone syntheses.Dumont,J.-M.; Rumpf,P. Bulletin de la Societe Chimique de France, 1962 , p. 1213 – 1218. References