2-Fluoronitrobenzene is an organic compound with the formula FC6H4NO2. It is one of three isomeric fluoronitrobenzenes.Gerald Booth, "Nitro Compounds, Aromatic" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH: Weinheim, 2005. A colorless liquid, it is prepared from 2-nitrochlorobenzene using the Halex process:
Applications 2-Fluoronitrobenzene has application in the synthesis of Amoxapine,Guo Xia, et al. CN103570641 (2014 to Beijing Venturepharm Technology Co Ltd). Olanzapine,Jiban K. Chakrabarti, et al., US5229382 (1993 to Lilly Industries Ltd). an early synthesis of J-113,397, Deschloroclozapine,Thomas Daniel Aicher, et al. WO2003082877 (Eli Lilly and Co). See ex. 553, 554 & 582. and 11-Piperazinyl-dibenz[b,f][1,4]oxazepane [21636-40-8].Jain, Manoj S.; Surana, Sanjay J. (2017). "Synthesis and evaluation of antipsychotic activity of 11-(4′-(N-aryl carboxamido/N-aryl-α-phenyl-acetamido)-piperazinyl)-dibenz[b,f][1,4]-oxazepine derivatives". Arabian Journal of Chemistry. 10: S2032–S2039. doi:10.1016/j.arabjc.2013.07.033.
The closely related compound, 2-chloronitrobenzene is used in the synthesis of quetiapine.
References