S60 or S-60 may refer to:
Automobiles S-60 (tractor), a Soviet tractor Toyota Crown (S60), a sedan Volvo S60, a compact executive car
Aviation Blériot-SPAD S.60, a French biplane fighter Kenmore Air Harbor, in Kenmore, Washington, United States Sikorsky S-60, a prototype American flying crane
Consumer electronics S60 (software platform), for mobile devices Canon PowerShot S60, a digital camera Cat S60, a mobile phone Pentax Optio S60, a digital camera
Rail and transit S60 (Long Island bus), United States S60 (RER Fribourg), a railway line in Switzerland S60, a regional railway service operating over the Lugano–Ponte Tresa Railway in Ticino, Switzerland S60, a line of the Stuttgart S-Bahn in Germany S60, a line of the Vienna S-Bahn in Austria
Other uses AZP S-60, a Soviet anti-aircraft gun , a submarine of the Indian Navy S60: This material and its container must be disposed of as hazardous waste, a safety phrase S60-class submarine, of the Spanish Navy S60 Shangqiu–Dengfeng Expressway, in China S60, a postcode district Rotherham, England