Golpaygani, alternatively spelled Golpayegani, () is an Iranian surname. Notable people with the surname include:
Akbar Golpayegani (1934–2023), Iranian traditional singer Hashem Bathaie Golpayegani (1941–2020), Iranian Shia Ayatollah Lotfollah Safi Golpaygani (1919–2022), Iranian Grand Ayatollah Mohammad Mohammadi Golpayegani (born c. 1943), Chief of Staff of the Office of the Supreme Leader of Iran Mohammad-Reza Golpaygani (1899–1993), Iranian Grand Ayatollah