Insfrán is a Spanish surname. Notable people with the surname include:
Antonio Insfrán (born 1942), Paraguayan footballer Benjamin Insfran (born 1972), Brazilian beach volleyball player Eligio Insfrán (born 1935), Paraguayan footballer Eliseo Insfrán (1935–2020), Paraguayan footballer Fernanda Insfrán (born 1998), Paraguayan handball player Gildo Insfrán (born 1951), Argentine politician Javier Insfrán (born 1999), Paraguayan rower José Insfrán (born 1949), Paraguayan footballer Nelson Insfrán (born 1995), Argentine footballer
See also Carlos Antonio López Ynsfrán (1792–1862), leader of Paraguay from 1841 to 1862 Edgar Ynsfrán (1921–1991), Minister of the Interior of Paraguay from 1956 to 1966 Facundo Ynsfrán (1860–1902), Vice President of Paraguay from 1894 to 1898