Pánuco () is a locality in the Mexican state of Zacatecas. It serves as the municipal seat of the eponymous Pánuco Municipality.
History Pánuco was founded on 1 November 1548 by explorers Diego de Ibarra, Francisco de Ibarra, and Cristóbal de Oñate. It became the seat of the eponymous municipality upon its foundation in 1824.
Demographics In the 2020 INEGI census, Pánuco recorded a population of 1,177 inhabitants living in 434 households.
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