Alikhani is a surname of Persian origin. Notable people with the surname include:
Alinaghi Alikhani (1929–2019), Iranian economist Ehsan Alikhani (born 1982), Iranian television presenter and director Ghodratollah Alikhani (born c. 1939), Iranian Shi'a cleric and politician Hossein Alikhani (died 2008), Iranian businessman Mohammad Alikhani (politician), Iranian politician Yousef Alikhani (born 1975), Iranian writer