Onofrei is a Romanian surname that may refer to:
Constantin Onofrei (born 9 May 1976), Romanian former professional boxer Octavian Onofrei (born 16 May 1991), Moldovan football forward Orest Onofrei (born 17 March 1957), Romanian veterinarian and politician Liliana Nicolaescu-Onofrei (born 6 November 1968), Moldovan politician