Samuel or Sam Locke may refer to:
Samuel Locke (educator) (1732–1778), American clergyman and educator Samuel Locke (politician) (1836–1890), New Zealand politician Sam Locke (screenwriter) (1917–1998), American writer and director Sam Locke (golfer) (born 1998), Scottish professional golfer Sam Locke (actor) (born 2001), Welsh actor
See also Samuel Loch (born 1983), Australian rower